Endocrine Abstracts

Introduction: Pituitary tumorous hyperplasia with hyperprolactinemia has been described as a rare presentation of primary hypothyroidism. The loss of thyroxin feedback inhibition in primary hypothyroidism causes overproduction of thyrotropin-releasing-hormone (TRH), which results in secondary pituitary enlargement. TRH has a weak stimulatory effect on the lactotroph cells of the pituitary, so a mild to moderate increase in prolactin (PRL) levels is expected. This report descri...

Aim: Ghrelin plays an important role in the stimulation of food intake and long-term regulation of body weight. In present study we investigate the long term effect of exenatide treatment on serum fasting ghrelin levels in patients with type 2 diabetes mellitus.Methods: Type 2 diabetic patients who were using metformin with and without the other oral antihiperglycemic drugs on a stable dose for at least 3 months were enrolled in the study. Body mass inde...

Introduction: Subacute thyroiditis (SAT) has been reported after COVID-19 infection and SARS-CoV-2 vaccination. SAT has a mild and self-limiting course. This is the first reported case of thyroid storm following the SARS-CoV-2 vaccineCase: A 32-year-old female patient had mild anterior neck pain, fatigue, tremor 2 weeks after being administered with the second dose of COVID-19 mRNA vaccine BNT162b2 (Pfizer–BioNTech). Initial biochemical investigatio...

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

Aim: Fibroblast growth factor (FGF) 21 is a hormone which plays an important role in metabolic diseases such as diabetes, obesity and dyslipidemia. In this study; we aimed to investigate the serum total and bioactive FGF21 levels in patients with gestational diabetes mellitus (GDM) and compared with healthy pregnant controls.Material and Methods: A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of...

Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum ...

Aim: To assess the contribution of macroprolactin (macroPRL) to high serum prolactin (PRL) levels and association of prolactin and macroprolactin levels with thyroid status and thyroid autoimmunity during pregnancy.Methods: Pregnant women (n=138) who had undergone a thyroid-stimulating hormone (TSH) screening during the first trimester of pregnancy enrolled in the study. Serum prolactin, macroprolactin, TSH, FT4, FT3, and thyroid autoantibodies ...

Although subclinical Cushing’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...

The relationship between increased risk of cardiovascular disease (CVD) and atherosclerosis in subclinical hypothyroidism (sHT) have been demonstrated in several studies. This relation was attributed to dyslipidemia which is common in sHT. Apo A1, apo B100, Lp (a), hsC-reactive protein (hsCRP), fibrinogen and total homocysteinemia (tHcy) are the main non-traditional cardiovascular risk factors. In addition, paraoxon 1 (PON 1) activity is an enzyme responsible for the anti-oxid...

Hyperinsulinemia that occurs due to insulin resistance play an important role on the development of type 2 diabetes and hypertension. It is shown that apart from their angiotensin II receptor blockage effect, telmisartan and irbesartan can activate intracellular hormone receptor PPARγ. Owing to this dual effect, telmisartan and irbesartan can improve cardiovascular risk factors related to insulin resistance. The aim of this study was to compare the effects of telmisartan ...